Genetische Veranlagung für Schizophrenie korreliert mit genetischer Veranlagung für erhöhten Cannabiskonsum
Molecular Psychiatry (2014), RA Power e. a.
http://www.nature.com/mp/journal/v19/n11/abs/mp201451a.html

Genetische Veranlagung für Cannabiskonsum erhöht Risiko für Schizophrenie
Julien Vaucher e. a.
http://www.biorxiv.org/content/biorxiv/early/2016/12/07/092015.full.pdf

CBD normalisiert Erinnerungsvermögen und soziales Verhalten bei Schizophrenie im Nagetiermodell
PhD candidate Ashleigh Osborne and her supervisors, Dr Katrina Green and Professor Nadia Solowij from the University of Wollongong (UOW), initially uncovered the fascinating insights about the therapeutic potential of CBD during a detailed review of 27 existing studies. Published in Neuroscience and Biobehavioral Reviews (Osborne et al, Jan 2017. 72:310-324 https://www.ncbi.nlm.nih.gov/pubmed/27884751). This evidence inspired Ms Osborne to investigate whether CBD can improve cognitive impairment in a rodent model of schizophrenia, together with her supervisors and research team members, Senior Professor Xu-Feng Huang and PhD candidate Ilijana Babic. “We found that CBD was able to restore recognition and working memory, as well as social behaviour to normal levels,” Ms Osborne said. Published in Neuropsychopharmacology, (Osborne et al, https://www.ncbi.nlm.nih.gov/pubmed/28230072).

Kontrollierte Studien

Cannabidiol (CBD)

Leweke FM, Koethe D, Gerth CW, Nolden BM, Schreiber D, Hänsel A, Neatby MA, Juelicher A, Hellmich M, Klosterkötter J. Cannabidiol as an antipsychotic. A double-blind, controlled clinical trial on cannabidiol vs. amisulpride in acute schizophrenia. IACM 3rd Conference on Cannabinoids in Medicine, 9-10 September 2005, Leiden, International Association for Cannabis as Medicine.

Zuardi AW, Hallak JE, Dursun SM, Morais SL, Faria Sanches R, Musty RE, Crippa JA. Cannabidiol monotherapy for treatment-resistant schizophrenia. J Psychopharmacol 2006;20(5):683-6.

Unkontrollierte Studien

Cannabidiol

Zuardi AW, Morais SL, Guimarães FS, Mechoulam R. Antipsychotic effect of cannabidiol. Journal of Clinical Psychiatry 1995;56:485-486.

Fallberichte, Umfragen

Dronabinol

Schwarcz G, Karajgi B, McCarthy R. Synthetic delta-9-tetrahydrocannabinol (dronabinol) can improve the symptoms of schizophrenia. J Clin Psychopharmacol 2009;29(3):255-8.

Schwarcz G, Karajgi B. Improvement in refractory psychosis with dronabinol: four case reports. J Clin Psychiatry. 2010;71(11):1552-3.

Fallberichte, Umfragen

Cannabis (geraucht)

Schwarcz G, Karajgi B, McCarthy R. Synthetic delta-9-tetrahydrocannabinol (dronabinol) can improve the symptoms of schizophrenia. J Clin Psychopharmacol 2009;29(3):255-8.

Schwarcz G, Karajgi B. Improvement in refractory psychosis with dronabinol: four case reports. J Clin Psychiatry. 2010;71(11):1552-3.